NIHR CLAHRC YH has developed the largest, nationally recruited Trials within Cohorts (TwiCs) platform of older people with frailty that includes over 800 participants. 88% of CARE75+ participants have consented to be approached about other studies. This research platform is available to health services researcher to enable research of older people across the frailty spectrum.
Demonstrated feasibility of national recruitment has been demonstrated, with varying population demographics and levels of social deprivation. Our current n = 850, with an age range of 75 years to 104 years and with approximately 9% recruited from the Black, Minority Ethnic community.
National roll-out within the CLAHRC community was facilitated by developing a bespoke Electronic Data Capture tool with our industry partner TigerTeam. CLAHRC YH are in the process of sub-licencing the tool for use in other research, thus generating revenue between Medipex, Bradford Teaching Hospitals FT and inventors.
CARE75+ has provided data to investigate research in: pain impact and frailty; agreement between frailty measures; pain, frailty and disability; frailty and cold homes; and frailty and mental health outcomes. CARE75+ data is providing estimates for health economic modelling on an NIHR programme grant, and provided participants for qualitative projects investigating resilience, communication, quality of life, and blood pressure; and participants for the MUSCLE study (Leeds Institute of Rheumatic and Musculoskeletal Medicine) investigating new scanning technologies.
The Frailty Oversight Group provides public and patient scrutiny of potential sub-studies and data requests to ensure CARE75+ is used appropriately.
CARE75+ has provided data to investigate research in: pain impact and frailty; agreement between frailty measures; pain, frailty and disability; frailty and cold homes; and frailty and mental health outcomes
Contribution of CLAHRC Yorkshire and Humber
CLAHRC funding has paid for the set-up and expansion of CARE75+, funding key roles including the project manager, researcher posts and equipment. Links with other CLAHRCs has enabled expansion to sites in the South West Peninsula and West Midlands.
What happened next?
The aim is to recruit 1000 older people to CARE75+. As numbers increase in the cohort and data is available at multiple time-points, it is now possible to undertake longitudinal analysis of the data. Additionally, the cohort will soon be at the capacity to support feasibility randomised controlled trials. It is intended to promote CARE75+ via a bespoke website and with continued engagement with CLAHRC national partners.