Antidepressants are drugs often prescribed as the first-line of treatment for adults with moderate to severe depression. However, only a third of people get better after taking these drugs.
The researchers will undertake two linked reviews to examine clinical trials of psychological therapies (treatment through talking with a mental health professional) or drug treatments in patients who have not responded sufficiently to initial drug therapy.
The reviews aim to determine if these treatments improve symptoms of depression, social functioning, quality of life, adverse events such as completed or attempted suicides and economic outcomes such as absence from work and use of health care resources.
The reviews will inform clinical decision making for the next step for adults with depression who have not responded to first-line treatment.