Trial of the clinical and cost-effectiveness of a specialist expert mood disorder team for treating depressionThe clinical and cost effectiveness of a specialist mood disorders team for refractory unipolar depressive disorder

East MidlandsMental Health
Start Date: 1 Jan 2014

Study aims

  • The Mood Disorders study was originally part of CLAHRC NDL, one of two precursor CLAHRCs in the East Midlands from 2008-13.
  • The study measured the implementation of NICE guidelines for depression so that the standard of care, offered by both treatment as usual and the specialist mood disorder team, could be judged externally.


  • Mental disorder accounts for 40 per cent of all disability in Europe and 40 per cent of incapacity benefit claims in England. In 1990, unipolar depression was the fourth leading cause of “disability adjusted life years” in the world and by 2020 it is projected to be the second leading cause.
  • The majority of suicides are associated with unipolar depression. Suicides in East Midlands have increased by one per cent in contrast to a national drop of six per cent (Anderson, 2006).

What the benefits will be

Improved care for patients with a clinical diagnosis of unipolar depressive disorder that has not been resolved within six months in three local mental health services. We also aim to understand whether better implementation of standard care outlined by NICE guidelines for depression or enhanced specialist care providing pharmacotherapy and psychotherapy is required.

Prof Richard Morriss